Mar Vista High (4-3) hosts San Ysidro High (1-6) in the Metro South Bay opener for each team.
Last week, Rommel Cooper scored three touchdowns and rushed for 219 yards on 22 carries Mar Vista High overcame a 20-0 first-quarter deficit to edge Sweetwater 28-26.
Mar Vista completed the non-league portion of its schedule with a 4-3 record and three consecutive victories.
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The three-game Metro South Bay schedule concludes with a visit to Hilltop on Nov. 5 and a home finale against Southwest on Nov. 12.
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