Mpox Cases On The Rise In San Diego County, Health Officials Warn

Officials say evidence of local transmission has prompted increased monitoring and renewed vaccination efforts.

By Kristina Houck, Patch Staff

Nov 13, 2026 12:12 PM PST

Although most infections are mild, the two-dose JYNNEOS vaccine protects against both types of mpox and helps prevent severe illness, hospitalization and death, officials said. (Peggy Bayard/Patch)

SAN DIEGO, CA — San Diego County health officials are expanding outreach efforts amid a rise in mpox infections, with 16 cases confirmed since October and 48 reported so far this year.

The county reported 35 cases in all of 2025.

Mpox spreads through close physical contact, including sexual contact. Two types of the virus, Clade I and Clade II, cause illness in humans. Clade II has accounted for most local cases since mpox emerged in the region in 2022.

Clade I has circulated in California since 2025. San Diego County health officials have confirme 10 cases of Clade I mpox since July, with evidence suggesting the virus is spreading locally.

Of the 16 cases reported since October, 10 involved people who were not vaccinated, according to health officials.

"With this recent increase in local cases, we are reminding people at risk to get the two-dose vaccine as soon as possible," said Dr. Ankita Kadakia, the county's deputy public health officer. "It remains the best way to protect yourself and those around you. If you still need the second dose, it is never too late to receive it."

Symptoms include a rash, fever, swollen lymph nodes, body aches and fatigue. The rash or sores can appear anywhere on the body, including hands, feet, chest, face, mouth and genitals.

Although most infections are mild, the two-dose JYNNEOS vaccine protects against both types of mpox and helps prevent severe illness, hospitalization and death, officials said.

Mpox cases in San Diego County peaked at 469 in 2022 and have remained below 100 annually since then.

In response to the recent increase, the county has begun reporting mpox cases weekly instead of monthly.

Health officials encourage people at increased risk or those who may have been exposed to contact their health care provider about vaccination. Vaccines are available through county sexual health clinics, including for uninsured and underinsured residents.

For more information, visit the county's mpox webpage. Residents can also sign up for updates by texting COSD MPOX to 98256.