The series matches two wild-card teams that both upset division champions in the National League Division Series.
The Padres defeated the Los Angeles Dodgers, 5-3, Saturday night, at Petco Park to win a National League Division Series three games to one.
It will be the first postseason game at Petco Park with fans since 2006.
Jake Cronenworth and Manny Machado each hit solo home runs in the Padres 5-3 win over the Dodgers to even the series at one game apiece.
"They handed it to us pretty good this year, so we realize what we're up against," Padres manager Bob Melvin said at a news conference.
Australian Ellen Perez was among six players qualifying for the singles main draw of the San Diego Open WTA 500 women's tennis tournament.
Joe Musgrove pitched the San Diego Padres into a National League Division Series matchup against the Los Angeles Dodgers.
First-round singles play began in the second annual $612,000 San Diego Open ATP 250 men's tournament at Barnes Tennis Center.
California, famous for being an innovator, is late to adopt sports betting.
San Diego State athletics will have a new radio home at San Diego Sports 760 – which calls itself “America’s Finest Sport Station.”
Tatis, who will begin serving his suspension, was using a medication containing a banned substance to treat ringworm, he said.
The San Diego Padres reportedly reached an agreement to trade for superstar outfielder Juan Soto.
The San Diego State men's basketball team will open play in the Maui Invitational against Ohio State Nov. 21.
Del Mar's summer meet begins Friday, with all available tickets sold for the 10-race card.
Gonzaga and Michigan State will face off on Nov. 11 aboard the flight deck of the USS Abraham Lincoln at Naval Air Station North Island.
The Padres Alumni softball game is set to return.
The golfers who have been suspended include six-time PGA major champion and San Diego native Phil Mickelson.
The San Diego Wave Fútbol Club rebounded from its first regular-season loss with a 1-0 victory over the North Carolina Courage.
The Padres are starting another baseball season in fine fashion.
Wave FC led 19-9 in shots and 7-3 in shots on goal before a crowd announced at 5,000.
The San Diego Gulls fired coach Joel Bouchard and assistant coaches Daniel Jacob and Max Talbot.
The San Diego Wave Fútbol Club defeated the Houston Dash in its first National Women's Soccer League regular-season game.
The jersey patch partnership is the first of its kind across all 30 Major League Baseball clubs.
The Aztec Advantage is a name, image and likeness program intended to educate student-athletes about their rights and opportunities.
He will replace Sam Scholl, who was fired earlier in March after going 15-16, the third consecutive losing season for the program.
San Diego-born Taylor Fritz defeated Rafael Nadal at Indian Wells Tennis Garden.
Collapses at the end of regulation and overtime doomed San Diego State in a 72-69 loss to Creighton Thursday evening.
Eighth-seeded San Diego State will face ninth-seeded Creighton in a Midwest Region first-round game Thursday in Fort Worth, Texas.
The teams that will play first-round NCAA men's basketball tournament games at Viejas Arena on Friday will conduct practices there Thursday.
Fernando Tatis Jr., the star shortstop for the San Diego Padres, broke his wrist in the offseason and could miss months, the team said.
Oddsmakers have made the SDSU Aztecs a 2-point to 2-1/2-point favorite.
Extreme sports legend and Carlsbad native Shaun White plans to retire after competing in the Beijing Winter Olympics.
The XXIV Olympics in Beijing starts Friday with three competitors from the San Diego area shooting for gold. Here's how to watch them.
Luke List birdied the first hole of a sudden-death playoff to defeat Will Zalatoris to win the $8.4 million Farmers Insurance Open.
American golfers Justin Thomas and Adam Schenk shared the lead Friday morning for Round 3 of the Farmer's Insurance Open at Torrey Pines.
The 70th anniversary edition of the $8.4 million Farmers Insurance Open begins Wednesday at Torrey Pines Golf Course.
The league, all NFL team owners and the city of San Diego are named as defendants.
The Gulls organization continues to follow enhanced protocols at the direction of team medical staff and the AHL, according to the league.
If the game cannot be rescheduled it will be declared a no contest, conference officials said.
The game was postponed due to COVID-19 issues with the Fresno State program, the Mountain West Conference announced Sunday.