Health & Fitness
A 9/11 Widow Overcomes 50 Years of Severe Depression
After 50 years of depression, a local widow found hope with an innovative treatment at Hackensack Meridian Health.

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For nearly 50 years, Loisanne Diehl lived under the crushing weight of severe depression—a struggle that only compounded into complicated grief after losing her husband in the September 11 attacks. She tried an astonishing 40 to 50 different medications, endured hospitalizations, and eventually had to move in with her daughter when she lost the ability to care for herself. At her absolute lowest, she feared for her own life.
But beneath the hopelessness, Loisanne kept fighting for an answer.
Her journey led her to Nitin J. Pothen, M.D., a psychiatrist at Hackensack Meridian Health, who realized she was suffering from treatment-resistant depression. Instead of prescribing yet another traditional daily pill that wouldn't work, Dr. Pothen introduced her to an innovative FDA-approved nasal spray called Spravato®. Unlike typical antidepressants, this groundbreaking therapy works differently in the brain to strengthen nerve connections and build neuroplasticity.
Today, Loisanne isn't just surviving—she is thriving. She is reconnecting with loved ones, writing poetry, and traveling the world again.
What was the exact moment Loisanne realized her 50-year darkness was finally lifting, and how does this revolutionary therapy work?
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