The 23-year-old man was thrown from the motorcycle in the crash, New Jersey State Police said.
The crash occurred around 6 a.m. on Friday when a vehicle driving west in the east lane collided with multiple vehicles, authorities said.
New Jersey State Police said the crash closed two lanes to drivers.
The woman was 9 months' pregnant with the couple's first child, according to a report.
All lanes are open, but no other information is available on the crash.
Drivers are asked to avoid the area, in a traffic alert from the Ocean County Sheriff's Office.
Traffic westbound is shut down and detoured in the area, authorities said.
"This is every parent’s worst nightmare," Prosecutor Bradley D. Billhimer said. The investigation is continuing.
A 6th person suffered minor injuries in the Honda-Dodge crash early Saturday that caused both vehicles to break in half, authorities said.
A downed traffic signal on Route 88 in Lakewood has prompted delays Thursday morning, authorities said.
Drivers should expect delays in the area for the duration of the road construction in the area, police said.
Authorities are urging people to avoid the area due to traffic congestion.
Vermont Avenue has a new signal that now is operational, Lakewood police said.
Motorists are being urged to avoid both areas because of significant traffic disruptions.
Downed wires and a downed pole on Route 88 in Lakewood has prompted commuting delays in the area Wednesday morning, authorities said.
A debris spill on the Garden State Parkway in Lakewood has prompted commuting delays in the area Thursday morning, authorities said.
The New Jersey Department of Transportation is warning commuters of a brush fire on the Garden State Parkway Friday morning.
A downed tree in on Route 88 in Lakewood has prompted commuting delays in the area Monday morning, authorities said.
The officer was flown to Jersey Shore University Medical Center for treatment, officials said.
A motor vehicle crash in Lakewood has prompted commuting delays in the area Thursday morning, authorities said.
The bus had students on board at the time of the crash, according to the report.
Mark Mandel, 36, died of his injuries at the scene of the crash on Wednesday morning, Lakewood police said.
One person was critically injured in the crash, according to a report.
Ocean County Sheriff's Officer Brian Stockhoff, 41, died at the scene of the crash on Shorrock Street, police said.
A salt-spreading truck hit the pole and broke it, according to a report.
None of the students were injured, according to a report.
Both drivers were taken to area hospitals following the two-vehicle crash that left one on its roof, police said.
The man was hit near the entrance to the bus terminal in Lakewood; the driver has been cooperative, the prosecutor's office said.
Police are asking motorists to avoid the area.
First responders performed CPR on the girl all the way to the hospital in an attempt to save her life, police said.
Police said there was a slight impact on traffic in the area of Route 9 and Central Avenue.
A school bus has run off the road in Lakewood Wednesday afternoon; there are road closures, according to reports.
The vehicle ran off the entrance ramp and overturned, New Jersey State Police said.
Reports say there were several students on the bus, but no serious injuries. It's the sixth crash in six weeks involving a school bus.
Two school bus crashes happened on Thursday according to reports, and five have happened since mid-September.
A motor vehicle crash brought down a utility pole, authorities said.
Lakewood police said the driver may have suffered a medical episode before the crash; there were no injuries.
The bus wound up perched on one vehicle that ended up on its side, but police said none of the 15 students were injured.
The road is anticipated to reopen Thursday evening, police said.
The closure is for drainage repairs, officials said.