The APACHE III score stratified increasing Japanese patient risk across the full range of increasing severity of illness. Our exclusion of variables incorporated into the US-derived APACHE III mortality and LOS predictive equations, designed as surrogate measures to capture differences in practice style and hospital utilization in the United States, highlights an alternative analytic strategy to modify models in order to account for the cultural context in which clinical care is delivered. Despite the modification of the mortality model to account partially for differences in practice style, the applied model overpredicted risk of death in all but the highest decile of risk. Possible explanations for this miscalibration included variations in patient selection that were not effectively controlled for in the risk-prediction equation, the temporal dysymetry in the data-collection periods for the analyzed data bases, and differences in the timing of hospital discharge. buy dexone online
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