The work is scheduled to begin Sunday night.
Seek an alternate route if you plan to travel in the area of Middlesex Turnpike and Bedford Street Thursday afternoon.
Police are urging motorists to use caution.
The move is backed by businesses, who say it will make it easier to fill service-sector job openings.
The route changes are part of overnight roadwork between Dec. 2 and 7.
The ban is in effect until April 1.
Overnight roadwork will impact both sides of the highway this week.
More than 800 people died in drunken crashes over the Thanksgiving weekend between 2012 and 2016, according to MADD.
Allow extra time if you're traveling in the vicinity of the Route 3/128 interchange.
The $125,000 line item will allow the Middlesex3 Transportation Association to offer evening service.
The left two lanes are closed after too-tall truck tried to squeeze under a sign.
A fully engulfed vehicle just shy of I-95 in Burlington is backing up traffic.
The initial work activities beginning April 23 include tree clearing as well as underbrush removal.
The accident closed the road briefly Monday afternoon and power was cut to the area after a truck hit a utility pole.