Visions For Vacancies: Nice Building, But What Should Go There?

I'll admit, I know very little about the history of this building. But clearly there is more to it than meets the eye.

This Main Street location is probably a building you've driven past hundreds, if not thousands of times and never gave it a second look.

It's in an area zoned commercial/mixed use. It would seem to open up many possibilities.

Now it's your turn, once again, to play developer and planner. What should go there that would be a strong addition to the Main Street landscape?