How to Measure Cell-Mediated Cytotoxicity

Cell-mediated cytotoxicity is one of the main immune system mechanisms that helps our bodies identify, target, and kill cells that are infected or damaged by pathogens. Scientists study this process in order to harness its power for developing medications that intelligently fight bacteria, viruses, and infections, including cancer.

Measuring cell-mediated cytotoxicity in vitro is essential to the development of critical immunotherapies. There are multiple forms of cell-mediated cytotoxicity that must be understood, along with several different measurement methods, each with pros and cons.

This white paper – an 8-minute read – highlights the different types of cell-mediated cytotoxicity and offers an overview of various measurement methods. Read the white paper to learn about:

• Antigen-Specific Cell-Mediated Cytotoxicity
• Antibody-Dependent Cellular Cytotoxicity
• Natural Killer Cell-Mediated Cytotoxicity
• Chromium-51 Release
• Lactate Dehydrogenase (LDH) Release
• Calcein Release
• Staining to Detect Degranulation
• Flow Cytometry

For an overview of the white paper contents, preview the infographic below.

This post originally appeared on the Astarte Biologics blog and has been modified for Patch.