Researchers at City of Hope say they created a therapy that effectively uses Salmonella bacterium to kill tumors.
My monthly report about what's going on in City Hall
Trash and recycling services to remain on regular schedule this Friday and Saturday
A flex alert calling people to cut back on electricity has been issued due to the hot weather.
Despite massive opposition from anti-vaxxers, the governor has signed a law, eliminating the vaccine requirement personal belief exemption.
A driver led police through through Orange County at speeds well over 100 mph Tuesday.
Sen. Marco Rubio will hold an Irvine reception tonight in his bid to become the nation's first Latino president.
The nation's highest court has agreed to hear a local case challenging a union's right to charge fair share fees for collective bargaining.
Are the Geese Reading the new Signs?
Check out the Patch Jobs Board in your town for the newest listings.
Damian Newhart, the “rolled- sleeves bandit,’ became addicted to drugs as a dentist and started robbing banks to support his habit.
Humidity continues to build this week, bring a chance of heavy rain to the mountains and valleys, say forecasters.
Annual food drive stocks nonprofit's pantry shelves to help feed the needy during the summer.
Here are the candidates for the Traffic Advisory Group
Need a break from bad news? Here are a few of our favorite uplifting headlines and photos from Southern California.
Thomas Mann, RJ Cyler and Olivia Cooke reveal the most intense moment of filming this Sundance Festival gem.
Drowning, dry drowning, snakebites, hot cars--summer has some pitfalls to avoid. Here’s your survival kit.
A 14-year-old boy was killed, and his cousin was injured in a 3-car collision caused by a suspected drunk driver.
With selfie sticks becoming an increasing safety hazard, Disney is issuing a ban on the ubiquitous stick.
A series of rallies from West Hollywood to Long Beach, will mark this historic day that brought marriage equality to the United States.
Dry lightning, strong winds and an already parched landscape have prompted an increase in fire staffing this weekend.
Catholic Church leaders and opponents of same-sex marriage slam the court's historic ruling establishing the right to same-sex marriage.
Help local people in need by volunteering in Orange County - be a Hunger Hero!
With two competing plans to build new arenas moving forward, league officials, in the meantime, are searching for temporary arenas in LA.
Sheriff Hutchens initiates a major change in the proposed jail.
Over 2,000 participants will either run the 5K timed course or enjoy a leisurely run/walk participating in holiday themed activities.
A jury found Mission Viejo's live-in care facility Lonika Homes Inc. at fault for the death of a 15-year-old disabled boy.
The speed restrictions are intended to protect endangered whales, which can be killed or seriously injured in a ship strike.
Kiwanis's Pancakes Breakfast on 4th July
The local economy is expected to grow with new white collar positions and Obamacare-fueled healthcare jobs.
All Jimmy John's SoCal locations, including Isla Vista, will be selling freaky fast subs for only $1 during Customer Appreciation Day
Former Hewlett-Packard CEO Carly Fiorina will greet supporters at a $2,700 per plate dinner fundraiser in Laguna Beach.
Craig Wagner promoted to Assistant Vice President in religious lending division at First Bank
Police now say a trucker who got a 1-year sentence for leaving a woman dead on the 5 Freeway is a match for a 2004 murder-rape.
An OC attorney's proposed ballot measure sanction the murder of gays and lesbians doesn't have to be taken seriously, a judge rules.
Alec Scott Abraham, 20, had a record for dangerous driving leading up the Irvine crash that took two lives.
Gas prices have fallen daily for the past 38 days. Here are the best prices around to help you kick off the summer.
Lifetime Club 33 member and “Walt Dreamers Me” author is suing Disneyland for booting him from the club.
Continuing the discussion of the Police contract