Multiple storms have caused rock and mudslides in the area.
The closure happened just south of the tunnel, city officials said.
Mud and rock slides forced two closures in Malibu over the weekend.
Drivers should allow extra time to travel through the area, the City of Malibu said.
A strong storm continues to pelt the Southland with rain.
Drivers should be cautious of possible mud slides, rocks and debris in the road, the city said.
The coastal road had been closed due to mud and debris in lanes.
It is a safety precaution in burn areas where there were multiple mud and rock slides and closures during the last storms, officials said.
Lane closures should still be expected as work continues to clear drains, according to Cal Trans.
Cars were trapped on Pacific Coast Highway over the weekend after a storm caused debris flow on the road.
Downed power lines shut down Malibu Canyon Road Wednesday.
The road still is one-way in certain areas.
Deputies are on the scene, the City of Malibu said.
The City of Malibu warns drivers to expect ongoing delays for several hours.
The estimated completion time is 7 p.m. tonight.
Drivers should expect delays and leave early in order to reach their destinations on time.
Segments of a 20-mile Stretch of PCH will close down while crews work to stabilize hillsides and infrastructure damaged in the Woolsey fire.
Sheriff's Deputies are responding to the crash reported in the 32200 block of Pacific Coast Highway near Encinal Canyon Road.
The crash and rescue response prompted the closure of all westbound lanes of Pacific Coast Highway.
There were no immediate reports that anyone was seriously injured.
Motorists should expect traffic delays.
The incident was reported at 10:21 a.m.
A critically injured victim was airlifted to a hospital, according to a report from the scene in Malibu.
Drivers should expect traffic delays in the area.
The motorist was taken to a hospital for treatment of an unspecified injury.
Two people were airlifted from the scene and four were taken away in ambulances, the Los Angeles County Fire Department reported.
A traffic collision in Malibu has shut down lanes of Pacific Coast Highway.
The contractor will provide traffic control in the affected areas and will maintain at least one travel lane.
The expected time for the traffic lane to reopen is 2 p.m.
There will be alternating lane closures between the #1 to #2 lanes, but one lane in each direction will remain open at all times.
Starting Monday, Pacific Coast Highway is expected to be clogged up. If you get stuck in traffic, enjoy the gorgeous views.
A combination of five simultaneous construction projects are planned for next week.
Various construction projects throughout the week in Malibu are expected to cause an increase in traffic.
No estimate was given for when it would re-open.
Motorists should expect delays and allow extra time for traveling through Topanga Canyon or use alternative routes if possible.
Live power lines were down in the roadway when the crash occurred, prompting a SigAlert.
About four to five vehicles were stuck in mud and drivers had to be rescued but no one was injured, according to reports from the scene.
The crash occurred a mile north of Pacific Coast Highway about 9:30 a.m., according to the California Highway Patrol.
It was not immediately clear if anyone was injured or any vehicles were damaged in the incident on Pacific Coast Highway.
Drivers should expect delays and use alternate routes if possible. (BREAKING)